PREDICTING WHICH BLASTOCYSTS WILL DEVELOP INTO FETUSES: TIME INTERVAL FROM MORULAE TO BLASTOCYSTS IS A NOVEL AND USEFUL INDICATOR FOR SUCCESSFUL PREGNANCY

The increased use of blastocyst transfer has emphasized the importance selecting high-quality embryos. Analyses embryos in a time-lapse incubator system showed that zygotes with shortest intervals between first and second or third mitotic divisions were higher rate. Additionally, developed relatively faster to morulae blastocysts had implantation rates. However, useful indicators predict which will develop into fetuses without pregnancy loss have not yet been identified. Do time interval fetuses? We analyzed 208 derived from ICSI 177 patients September 2019 2020. All monitored by system. outcome vitrified-thawed single transfers was classified non-pregnancy groups. group divided ongoing loss. Data using multiple logistics regressions. According logistic analysis women age, data as less than more 39 years old. Time-lapse analyses provided on pronuclear fading (tM), expanded (tEB), (tB-tM), number equatorial trophectoderm cells (eTE), KIDScore D5 v3 (KS5). (hCG > 50 mIU/ml at 4 weeks) versus compared, well those (a gestational sac 12 In this study, 51.4% total resulted pregnancy. Significant differences found groups: tM, 63.0 vs. 65.8 h; tEB, 92.4 95.5 tM-t8, 29.5 32.2 eTE, 6.5 5.5; KS5, 6.7 5.8. rate old significantly over (67.4% 38.1%). Under 39-years-old, 79.7%, 20.3%. A longer tB-tM, eTE compared group. potential tB-tM for predicted an AUC 0.79. Over 72.1%, 27.9%. group, t2, t4 tM different suggested delay early embryonic development increases risk. old, are effective predictors selection be successful pregnant. is new indicator identifying blastocysts. embryo critical